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PROTO-ONCOGENE PROTEINS C-MET
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-met
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-met
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-met
Synonyms
English
:
HGF Receptor
Hepatocyte Growth Factor Receptor
c-met Proteins
met Proto-Oncogene Proteins
Tree Number:
D08.811.913.696.620.682.725.400.075
D12.776.543.750.060.186
D12.776.543.750.750.400.100
D12.776.624.664.700.186
Definition
English
:
Cell surface protein-tyrosine kinase receptors for
HEPATOCYTE GROWTH FACTOR
. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the
catalytic domain
and sites critical for the regulation of kinase activity. Mutations of the gene for
PROTO-ONCOGENE PROTEINS C-MET
are associated with papillary renal
carcinoma
and other neoplasia.
Indexing Annotation
English
:
DF: C MET
PROTEINS
History Note
English
:
2006, 1998-1999
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33476
Unique Identifier:
D019859
Occurrence in VHL
:
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CID-10
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